NMUR1 IN THE NMU-MEDIATED REGULATION OF BONE REMODELING

Neuromedin-U (NMU) is an evolutionarily conserved peptide that regulates varying physiologic effects including blood pressure, stress and allergic responses, metabolic and feeding behavior, pain perception, and neuroendocrine functions.Recently, several lines of investigation implicate NMU in regulating bone remodeling.For instance, global loss of

Nitric oxide donors and inhaled nitric oxide (iNO) may decrease ischemia/reperfusion injury as reported in animal and human models.We investigated whether the attenuation of reperfusion injury, seen by others, in patients undergoing knee arthroplasty could be reproduced when patients had spinal anesthesia.45 consecutive patients were randomized int